Dynaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity.

Artigo Acesso aberto Revisado por pares

Dynaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity.

1991; Springer Nature; Volume: 44; Issue: 12 Linguagem: Inglês

10.7164/antibiotics.44.1312

ISSN

1881-1469

Autores

James P. Karwowski, MARIANNA JACKSON, MARY L. MAUS, William L. Kohl, PATRICK E. HUMPHREY, PAULINE M. TILLIS,

Tópico(s)

Peptidase Inhibition and Analysis

Resumo

The dunaimycins are a new complex of spiroketal 24-membered macrolides discovered in the fermentation broth of two actinomycetes. Based on taxonomic studies these two cultures, which were isolated from soil, were identified as Streptomyces diastatochromogenes strains AB 1691Q-321 and AB 1711J-452. The dunaimycins possess both immunosuppressive and antimicrobial activity.

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Dynaimycins, a new complex of spiroketal 24-membered macrolides with immunosuppressive activity. I. Taxonomy of the producing organisms, fermentation and antimicrobial activity.