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Corticotropin like intermediate lobe peptide in the salmon pituitary.

1980; Springer Science+Business Media; Volume: 46; Issue: 6 Linguagem: Inglês

10.2331/suisan.46.743

1349-998X

Hiroshi Kawauchi, Kenichi Abe, Akiyoshi Takahashi,

Aquaculture Nutrition and Growth

An intermediate lobe peptide, which are relted to C-terminal region of corticotropin, ACTH (18-39) has been isolated from an alkaline extract of the pituitary gland of the salmon, Oncorhynchus keta, by salt precipiation, ion exchange chromtography, gel filtration and preparative paper electrophoresis. Sequence analysis of the peptide revealed the following primary structure: H-Arg-Pro-Val-Lys-Val-Tyr-Thr-Asn-Gly-Val-Glu-Gln-Ser-Ser-Glu-Gly-Phe-Pre-Ser-Glu-Met-OH. The amino acid sequence comparison suggested that the teleost peptide is much closer to the higher vertebrate, such as ostrich than the elasmobranch (dogfish).