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Brief Report: HIV Infection Is Associated With Worse Bone Material Properties, Independently of Bone Mineral Density

2016; Lippincott Williams & Wilkins; Volume: 72; Issue: 3 Linguagem: Inglês

10.1097/qai.0000000000000965

1944-7884

Robert Güerri‐Fernández, D. Molina, Judit Villar-García, Daniel Prieto‐Alhambra, Leonardo Mellibovsky, Xavier Nogués, Alicia González-Mena, Ana Guelar, Marta Trenchs-Rodríguez, Sabina Herrera, Juan Pablo Horcajada, Adolfo Díez‐Pérez, Hernando Knobel,

Bone health and osteoporosis research

Low bone mineral density (BMD) in HIV-infected individuals has been documented in an increasing number of studies. However, it is not clear whether it is the infection itself or the treatment that causes bone impairment. Microindentation measures bone material strength (Bone Material Strength index) directly. We recruited 85 patients, 50 infected with HIV and 35 controls. Median Bone Material Strength index was 84.5 (interquartile range 83-87) in HIV-infected patients and 90 (88.5-93) in controls (P < 0.001). No significant differences in BMD between cases and controls at any of the sites examined (total hip, femoral neck, and lumbar spine). HIV infection is associated with bone damage, independently of BMD.