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The loss of cyclosporine from solutions into the administration set.

1988; Japanese Society of Pharmaceutical Health Care and Sciences; Volume: 14; Issue: 5 Linguagem: Inglês

10.5649/jjphcs1975.14.335

2185-9477

Shinichiro Nakajima, Kenji Kawano, Kazuyoshi Nakazawa, KIMINORI TERADA,

Renal Transplantation Outcomes and Treatments

The loss of cyclosporine from solutions into the intravenous delivery system was investigated. Concentration of cyclosporine was measured with high-performance liquid chromatography. When the cyclosporine solution was passed through the administration set 100cm in length at a flow rate 0.58 m1/min, and initial concentration 49.5μg/ml, the concentration of cyclosporine was reduced to about 86% in 15 min, and gradually returned to the initial level with time.With the solutions stored in a glass or a polypropylene container no drug loss was observed but with a polyvinyl chloride bag the concentration of cyclosporine was reduced to 94.4%in 24 hr.It was found that the factors effecting on the loss of cyclosporine from intravenous solutions were the kind of containers, the length of the administration set, the concentration of cyclosporine injection and the flow rate of solutions.