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Plasma Xanthine Oxidase and Resistance to Hypoxia: Effect of Purines and Alcohol Administration

1991; De Gruyter; Volume: 9; Issue: 3-4 Linguagem: Inglês

10.1515/dmdi.1991.9.3-4.311

2191-0162

Lukáš Novák, S Štípek, Tomáš Zima, S Trojan,

Heme Oxygenase-1 and Carbon Monoxide

The administration of allopurinol significantly increased resistance to repeated hypobaric hypoxia, while hypoxanthine decreased it. The administration of adenine or inosine (25 mg/kg) was without effect. The results show pathogenic significance of xanthine oxidase-dependent production of free oxygen radicals in posthypoxic damage. In other experiments, the administration of 50% ethanol (12 ml/kg) by gastric catheter increased plasma xanthine oxidase activity in both rats and hamsters.