REACTIONS OF HYDRAZIDOYL HALIDES: SYNTHESIS OF IMIDAZO[2,1-B]THIAZOLE, THIAZOLO[2,3-C]-AS-TRIAZOLE AND HETEROCYCLIC ENAMINONITRILES
1988; Taylor & Francis; Volume: 36; Issue: 1-2 Linguagem: Inglês
10.1080/03086648808079007
ISSN0308-664X
AutoresAbdou O. Abdelhamid, Mamdouh A. M. Afifi,
Tópico(s)Synthesis and biological activity
ResumoAbstract Arylazo derivatives of imidazo[2,1-b]thiazoles could be obtained via reaction of hydrazidoyl halides with 2-aminothiazole. Thiazolo[2,3-c]-as-triazole and heterocyclic enaminonitriles were obtained in good yields from hydrazidoyl halides and triethylamine and from malonitrile, respectively. Pyrazolo[3,4-d]pyrimidines and pyrazolo[3,4-d]pyridazines were obtained via reaction of heterocyclic enaminonitriles with formic acid and hydrazine hydrate, respectively. The structures of the products were assigned and confirmed on the basis of their elemental analyses and spectral data.
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