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Endometrial Carcinoma after Stilbestrol Therapy in Gonadal Dysgenesis

1972; Massachusetts Medical Society; Volume: 287; Issue: 13 Linguagem: Inglês

10.1056/nejm197209282871302

1533-4406

Bruce S. Cutler, Anne P. Forbes, Francis M. Ingersoll, Robert E. Scully,

Sexual Differentiation and Disorders

Among 24 patients with gonadal dysgenesis who had been treated for five or more years with stilbestrol, endometrial carcinoma developed in two and possibly in a third. Three cases of endometrial carcinoma in patients with gonadal dysgenesis have previously been reported by others. Three of the five definite carcinomas were of an unusual mixed, or adenosquamous, type. The cancers were detected at an average age of 31 years. The only reported case of endometrial carcinoma in an untreated patient with primary amenorrhea occurred at the age of 79 years. The early age at occurrence of this unusual type of tumor suggests a carcinogenic role of exogenous estrogens in these patients.