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Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red seaweed Bostrychia radicans

2012; De Gruyter; Volume: 55; Issue: 4 Linguagem: Inglês

10.1515/bot-2011-0023

1437-4323

Cíntia Erbert, Adriana A. Lopes, Nair S. Yokoya, Niege Araçari Jacometti Cardoso Furtado, Raphael Conti, Mônica Tallarico Pupo, João Luís Callegari Lopes, Hosana Maria Debonsi,

Marine and coastal plant biology

Abstract Endophytic fungi isolated from the red seaweed Bostrychia radicans were studied to identify their molecularly diverse and biologically active natural chemical products. According to 28S ribosomal DNA-based identification, the strain named C81 was 98% identical to Phomopsis longicolla . This strain was cultivated in solid rice medium and produced three major metabolites identified as 18-deoxycytochalasin H ( 1 ), mycophenolic acid ( 2 ), and dicerandrol C ( 3 ). The chemical structures of these compounds were elucidated by 1D and 2D nuclear magnetic resonance as well as by mass spectrometry. Dicerandrol C had significant antimicrobial activity against Staphylococcus aureus (ATCC 6538) and Staphylococcus saprophyticus (ATCC 15305), with minimum inhibitory concentrations of 1 and 2 μg ml -1 (1.33 and 2.66 μ m ), respectively. These results show the presence of promising metabolites and indicate that these natural products should be considered in the development of new antibiotics.