Multifunctional Microgel Magnetic/Optical Traps for SERS Ultradetection
2011; American Chemical Society; Volume: 27; Issue: 8 Linguagem: Inglês
10.1021/la200266e
ISSN1520-5827
AutoresRafael Contreras‐Cáceres, Sara Abalde‐Cela, Pablo Guardia, A. Fernández-Barbero, Jorge Pérez‐Juste, Ramón A. Álvarez‐Puebla, Luis M. Liz‐Marzán,
Tópico(s)Advanced biosensing and bioanalysis techniques
ResumoWe report on the fabrication of a SERS substrate comprising magnetic and silver particles encapsulated within a poly(N-isopropylacrylamide) (pNIPAM) thermoresponsive microgel. This colloidal substrate has the ability to adsorb analytes from solution while it is expanded (low temperature) and reversibly generate hot spots upon collapse (high temperature or drying). Additionally, the magnetic functionality permits concentration of the composite particles into small spatial regions, which can be exploited to decrease the amount of material per analysis while improving its SERS detection limit. Proof of concept for the sequestration of uncommon molecular systems is demonstrated through the first SERS analysis of pentachlorophenol (PCP), a chlorinated ubiquitous environmental pollutant.
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