Portal de Periódicos da CAPES

Pulsatility of brachial artery pressure is associated with an increased risk of coronary artery disease in men

2001; Lippincott Williams & Wilkins; Volume: 19; Issue: 9 Linguagem: Inglês

10.1097/00004872-200109000-00010

1473-5598

Naotoshi Yamashita, Yasunori Nakayama, Kei Tsumura, Takahiro Nishijima, Hiroyasu Ueda, Kiyomichi Yoshimaru, Tomoshige Hayashi, Junichi Yoshikawa,

Coronary Interventions and Diagnostics

Objectives The purpose of this study was to evaluate whether the pulsatility of brachial artery pressure is related to an increased risk of coronary artery disease (CAD). On the basis of vascular mechanics, we recently reported that relative pulse pressure can predict the occurrence of restenosis after percutaneous transluminal coronary angioplasty. We also hypothesized that relative pulse pressure of the brachial arterial pressure waveform is associated with an increased risk of CAD. Design A cross-sectional study. Patients We enrolled 172 men who had the same cardiac performances. Main outcome measures We measured their brachial artery pressures with a sphygmomanometer. To quantify the relative magnitude of the pulsatility to diastolic pressure, we made use of the ratio of pulse pressure to diastolic pressure (PP/DP). We investigated the effects of the PP/DP in relation to the risk of CAD. Results PP/DP was associated with an increased risk of CAD. The prevalence rates of significant stenosis were 28.1% for the lowest, 43.1% for the middle and 49.1% for the highest tertile of PP/DP levels. The age-adjusted odds ratio of CAD was 2.23 (95% confidence interval 0.98–5.04) for the middle tertile of the PP/DP level and 2.55 (1.10–5.93) for the highest tertile compared with the lowest tertile. Conclusions The pulsatility of the brachial artery pressure was associated with an increased risk of CAD.