Unprecedented Diterpenoids as a PTP1B Inhibitor from the Hainan Soft Coral Sarcophyton trocheliophorum Marenzeller
2012; American Chemical Society; Volume: 15; Issue: 2 Linguagem: Inglês
10.1021/ol303110d
ISSN1523-7060
AutoresLin‐Fu Liang, Tibor Kurtán, Attila Mándi, Li‐Gong Yao, Jia Li, Wen Zhang, Yue‐Wei Guo,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoMethyl sarcotroates A and B (3 and 4), two unprecedented diterpenoids possessing a tetradecahydrocyclopenta[3′,4′]cyclobuta[1′,2′:4,5]cyclonona[1,2-b]oxirene ring system, along with their probable biogenetic precursor, sarcophytonolide M (1), were isolated from the Hainan soft coral Sarcophyton trocheliophorum. Their structures were elucidated by detailed spectroscopic analysis, and the absolute configuration of compound 3 was determined by TDDFT ECD calculations. Compound 4 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), being similar to that of positive control oleanolic acid.
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