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Lumpectomy Compared with Lumpectomy and Radiation Therapy for the Treatment of Intraductal Breast Cancer

1993; Massachusetts Medical Society; Volume: 328; Issue: 22 Linguagem: Inglês

10.1056/nejm199306033282201

1533-4406

Bernard Fisher, Joseph P. Costantino, Carol Redmond, Edwin R. Fisher, Richard G. Margolese, Nikolay Dimitrov, Norman Wolmark, D. Lawrence Wickerham, Melvin Deutsch, Liora Ore, Eleftherios P. Mamounas, William R. Poller, Maureen Kavanah,

Cancer and Skin Lesions

Women with ductal carcinoma in situ have been treated both by lumpectomy and by lumpectomy followed by radiation therapy, but the benefit of combined therapy is uncertain. A group of 818 women with ductal carcinoma in situ were randomly assigned to undergo lumpectomy or lumpectomy followed by breast irradiation (50 Gy). Sufficient tissue was removed that the margins of the resected specimens were histologically tumor-free. The mean duration of follow-up was 43 months (range, 11 to 86). The principal end point of the study was event-free survival, as defined by the presence of no new ipsilateral or contralateral breast cancers, regional or distant metastases, or other cancers and by no deaths from causes other than cancer.