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Oral Treatment of Pernicious Anemia with Vitamin B 12 without Intrinsic Factor

1955; Massachusetts Medical Society; Volume: 253; Issue: 12 Linguagem: Inglês

10.1056/nejm195509222531204

1533-4406

Edward H. Reisner, Leo Weiner, Marilyn T. Schittone, Edwin A. Henck,

Porphyrin Metabolism and Disorders

THE absorption of ordinary amounts of vitamin B12 from the gastrointestinal tract is normally dependent on the presence of the intrinsic factor of Castle in the gastric secretions. A lack of intrinsic factor results in deficient absorption of vitamin B12 and the clinical picture of pernicious anemia. In the treatment of this condition it has been necessary either to administer vitamin B12 parenterally or to add intrinsic factor to the vitamin B12 given by mouth to ensure proper absorption. If, however, the oral dose of vitamin B12 is increased to more than 1 mg. enough . . .