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Purification of a novel cytolytic protein from albumen gland of the sea hare, Dolabella auricularia.

1989; Pharmaceutical Society of Japan; Volume: 37; Issue: 10 Linguagem: Inglês

10.1248/cpb.37.2773

1347-5223

Jun Kisugi, Masatoshi Yamazaki, Yasuhiro Ishii, Shigeru Tansho, Koji Muramoto, Hisao Kamiya,

Invertebrate Immune Response Mechanisms

A novel cytolytic factor, dolabellanin A, was purified to apparent homogeneity from the albumen gland of the sea hare Dolabella auricularia. Purified dolabellanin A was a glycoprotein of 250 kilo daltons containing 4 subunits. The amino acid composition and the N-terminal amino acid sequence of the factor were also determined. The factor is distinct from antineoplastic glycoproteins previously isolated from another sea hare, Aplysia kurodai. These results suggest that dolabellanin A found in the sea hare of the Dolabella species is a new cytolytic factor.