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Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis

2014; SAGE Publishing; Volume: 21; Issue: 11 Linguagem: Inglês

10.1177/1352458514561910

1477-0970

Melissa Sorosina, Federica Esposito, Clara Guaschino, Ferdinando Clarelli, Nadia Barizzone, Ana Maria Osiceanu, Paola Brambilla, Elisabetta Mascia, Paola Cavalla, Paolo Gallo, Vittorio Martinelli, Maurizio Leone, Giacomo P. Comi, Sandra D’Alfonso, Filippo Martinelli Boneschi,

Peripheral Neuropathies and Disorders

We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n=906) and progressive-onset MS Italian patients (PrMS) ( n=544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= −0.1; p=5 × 10 −3 ) and a later age at onset in PrMS cases (rho=0.07; p=0.15) ( p of difference of regression=1.4 × 10 −2 ). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.