Portal de Periódicos da CAPES

Incidence of Dengue Virus Infection in School-Aged Children in Puerto Rico: A Prospective Seroepidemiologic Study

2015; American Society of Tropical Medicine and Hygiene; Volume: 92; Issue: 3 Linguagem: Inglês

10.4269/ajtmh.14-0231

1476-1645

D. Fermín Argüello, Kay M. Tomashek, Luz Quiñones, Manuela Beltrán, Luz N. Acosta, Luis M. Santiago, Brad J. Biggerstaff, Enid J García-Rivera, Wellington Sun, Laurence Pollissard-Gadroy, Christine Luxemburger, Elizabeth Hunsperger,

Malaria Research and Control

Dengue is a potentially fatal acute febrile illness caused by the mosquito-borne dengue viruses (DENV-1 to -4). To estimate DENV seroincidence in school-aged children, a 1-year prospective cohort study was conducted in Patillas, Puerto Rico; 10- to 18-year-olds ( N = 345) were randomly selected from 13 public schools. At enrollment, 49.8% of the entire cohort had DENV immunoglobulin G (IgG) anti-DENV antibodies, and there were individuals with neutralizing antibodies specific to each of the four DENV. The mean age of participants with incident DENV infection was 13.4 years. The 1-year seroincidence rate was 5.6%, and 61.1% of infections were inapparent. Having IgG anti-DENV at enrollment was associated with seroincidence (risk ratio = 6.8). Acute febrile illnesses during the study period were captured by a fever diary and an enhanced and passive surveillance system in the municipios of Patillas and Guayama. In summary, at enrollment, nearly one-half of the participants had a prior DENV infection, with the highest incidence in the 10- to 11-year-olds, of which most were inapparent infections, and symptomatic infections were considered mild.