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Glenodinine, an Ichthyotoxic Substance Produced by a Dinoflagellate, Peridinium polonicum

1968; Springer Science+Business Media; Volume: 34; Issue: 6 Linguagem: Inglês

10.2331/suisan.34.528

1349-998X

Yoshiro HASHIMOTO, Tomotoshi Okaichi, Le Dung DANG, Tamao Noguchi,

Marine Toxins and Detection Methods

In September 1962, the extensive water blooms of a dinoflagellate, accompanying mass mortality of fish, occurred for the first time in the Lake Sagami near Tokyo.This lake resulted from construction of a multipurpose dam in 1945.TOKUNAGA et al. (Personal communication) made a survey on the bloom and considered that the mortality of fish might be attributable to a water-soluble, ichthyotoxic substance produced by a dinoflagellate, tentatively identified as Glenodinium sp. by them.Since 1963, we have attempted to isolate the ichthyotoxic substance from the plankton collected from the lake and succeeded in obtaining it in the pure state.The substance was confirmed to be an alkaloid showing a resemblance to ibogaalkaloid in the mass spectrum and to contain a sulfhydryl radical in the molecule.We designated it as glenodinine and will use the name for convenience, although the dinoflagellate in question was later identified, on our request, as Peridinium polonicum by ADACHI.1)The present paper deals with the bioassay method, isolation, and some physiological and che mical properties of glenodinine.