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Dose-Dependent Effect of an Oral Adsorbent, AST-120, in Patients with Early Chronic Renal Failure

2002; SAGE Publishing; Volume: 30; Issue: 5 Linguagem: Inglês

10.1177/147323000203000501

1473-2300

Noriaki Yorioka, Tomotaka Ito, Takao Masaki, Satoshi Ogata, Yukiteru Asakimori, Chie Tanji, Yasufumi Kyuden, Yutaka Komiya, Junko Kumagai, Y Taniguchi, Nobuoki Kohno,

Chronic Kidney Disease and Diabetes

We evaluated the dose dependence of an oral adsorbent, AST-120, in 31 patients with early chronic renal failure (baseline serum creatinine: 1.2–3.0 mg/dl). Twenty-three patients were given AST-120 and eight patients were not. AST-120 was administered at three different maintenance doses, < 3.0 g, 3.0 g and 6.0 g/day, according to patients' ability to tolerate treatment. The treatment period was 12 months. The slope of the reciprocal of serum-creatinine concentration versus time was calculated to assess the progression of renal failure. This slope became significantly less steep after AST-120 treatment at 6.0 g/day, but did not change significantly at the other doses. These findings suggest that 6.0 g/day of AST-120 may delay the initiation of dialysis in patients with early chronic renal failure.