Can Microbiota Research Change Our Understanding of Neurodegenerative diseases?
2016; Future Medicine; Volume: 6; Issue: 2 Linguagem: Inglês
10.2217/nmt-2015-0012
ISSN1758-2032
Autores Tópico(s)Clostridium difficile and Clostridium perfringens research
ResumoNeurodegenerative Disease ManagementVol. 6, No. 2 CommentaryCan microbiota research change our understanding of neurodegenerative diseases?Filip ScheperjansFilip Scheperjans*Author for correspondence: E-mail Address: filip.scheperjans@hus.fi Department of Neurology, Helsinki University Hospital & Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, FinlandPublished Online:1 Apr 2016https://doi.org/10.2217/nmt-2015-0012AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: Alzheimer's diseaseamyloidamyotrophic lateral sclerosisbiomarkergut–brain-axismicrobiomemicrobiotaneuroinflammationParkinson's diseaseReferences1 Qin J, Li R, Raes J et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464(7285), 59–65 (2010).Crossref, Medline, CAS, Google Scholar2 Baquero F, Nombela C. The microbiome as a human organ. Clin. Microbiol. Infect. 18(Suppl. 4), 2–4 (2012).Crossref, Medline, CAS, Google Scholar3 Lederberg J, McCray AT. 'Ome SweetOmics – a genealogical treasury of words. Scientist 15(7), 8 (2001).Google Scholar4 Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature 486(7402), 207–214 (2012).Crossref, Medline, Google Scholar5 Maheshwari P, Eslick GD. Bacterial infection and Alzheimer's disease: a meta-analysis. J. Alzheimers Dis. 43(3), 957–966 (2015).Crossref, Medline, Google Scholar6 Agostini S, Clerici M, Mancuso R. How plausible is a link between HSV-1 infection and Alzheimer's disease? Expert Rev. Anti Infect. Ther. 12(3), 275–278 (2014).Crossref, Medline, CAS, Google Scholar7 Alonso R, Pisa D, Marina AI, Morato E, Rabano A, Carrasco L. Fungal infection in patients with Alzheimer's disease. J. Alzheimers Dis. 41(1), 301–311 (2014).Crossref, Medline, CAS, Google Scholar8 Alonso R, Pisa D, Marina AI et al. Evidence for fungal infection in cerebrospinal fluid and brain tissue from patients with amyotrophic lateral sclerosis. Int. J. Biol. Sci. 11(5), 546–558 (2015).Crossref, Medline, CAS, Google Scholar9 Dobbs SM, Dobbs RJ, Weller C, Charlett A. Link between Helicobacter pylori infection and idiopathic Parkinsonism. Med. Hypotheses 55(2), 93–98 (2000).Crossref, Medline, CAS, Google Scholar10 Banack SA, Caller TA, Stommel EW. The cyanobacteria derived toxin Beta-N-methylamino-L-alanine and amyotrophic lateral sclerosis. Toxins (Basel) 2(12), 2837–2850 (2010).Crossref, Medline, CAS, Google Scholar11 Lim SL, Rodriguez-Ortiz CJ, Kitazawa M. Infection, systemic inflammation, and Alzheimer's disease. Microbes Infect. 17(8), 549–556 (2015).Crossref, Medline, CAS, Google Scholar12 Bu XL, Wang X, Xiang Y et al. The association between infectious burden and Parkinson's disease: a case–control study. Parkinsonism Relat. Disord. 21(8), 877–881 (2015).Crossref, Medline, Google Scholar13 Bravo JA, Forsythe P, Chew MV et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl Acad. Sci. USA 108(38), 16050–16055 (2011).Crossref, Medline, CAS, Google Scholar14 Bercik P, Denou E, Collins J et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology 141(2), 599–609, 609.e1–3 (2011).Crossref, Medline, CAS, Google Scholar15 Berer K, Mues M, Koutrolos M et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 479(7374), 538–541 (2011).Crossref, Medline, CAS, Google Scholar16 Miyake S, Kim S, Suda W et al. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridia XIVa and IV clusters. PLoS ONE 10(9), e0137429 (2015).Crossref, Medline, Google Scholar17 Yin J, Liao SX, He Y et al. Dysbiosis of gut microbiota with reduced trimethylamine-N-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack. J. Am. Heart Assoc. 4(11), e002699 (2015).Crossref, Medline, Google Scholar18 Hawkes CH, Del Tredici K, Braak H. Parkinson's disease: a dual-hit hypothesis. Neuropathol. Appl. Neurobiol. 33(6), 599–614 (2007).Crossref, Medline, CAS, Google Scholar19 Fasano A, Bove F, Gabrielli M et al. The role of small intestinal bacterial overgrowth in Parkinson's disease. Mov. Disord. 28(9), 1241–1249 (2013).Crossref, Medline, CAS, Google Scholar20 Forsyth CB, Shannon KM, Kordower JH et al. Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease. PLoS ONE 6(12), e28032 (2011).Crossref, Medline, CAS, Google Scholar21 Scheperjans F, Aho V, Pereira PA et al. Gut microbiota are related to Parkinson's disease and clinical phenotype. Mov. Disord. 30(3), 350–358 (2015).Crossref, Medline, Google Scholar22 Keshavarzian A, Green SJ, Engen PA et al. Colonic bacterial composition in Parkinson's disease. Mov. Disord. 30(10), 1351–1360 (2015).Crossref, Medline, CAS, Google Scholar23 Hasegawa S, Goto S, Tsuji H et al. Intestinal dysbiosis and lowered serum lipopolysaccharide-binding protein in Parkinson's disease. PLoS ONE 10(11), e0142164 (2015).Crossref, Medline, Google Scholar24 Goldman SM, Kamel F, Ross GW et al. Peptidoglycan recognition protein genes and risk of Parkinson's disease. Mov. Disord. 29(9), 1171–1180 (2014).Crossref, Medline, CAS, Google Scholar25 Lema Tome CM, Tyson T, Rey NL, Grathwohl S, Britschgi M, Brundin P. Inflammation and alpha-synuclein's prion-like behavior in Parkinson's disease-is there a link? Mol. Neurobiol. 47(2), 561–574 (2013).Crossref, Medline, CAS, Google Scholar26 Friedland RP. Mechanisms of molecular mimicry involving the microbiota in neurodegeneration. J. Alzheimers Dis. 45(2), 349–362 (2015).Crossref, Medline, CAS, Google Scholar27 Hill JM, Lukiw WJ. Microbial-generated amyloids and Alzheimer's disease (AD). Front. Aging Neurosci. 7, 9 (2015).Crossref, Medline, Google Scholar28 Scheperjans F, Pekkonen E, Kaakkola S, Auvinen P. Linking smoking, coffee, urate, and Parkinson's disease – a role for gut microbiota? J. Parkinsons Dis. 5(2), 255–262 (2015).Crossref, Medline, Google Scholar29 Kamer AR, Craig RG, Pirraglia E et al. TNF-alpha and antibodies to periodontal bacteria discriminate between Alzheimer's disease patients and normal subjects. J. Neuroimmunol. 216(1), 92–97 (2009).Crossref, Medline, CAS, Google Scholar30 Noble JM, Scarmeas N, Celenti RS et al. Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease. PLoS ONE 9(12), e114959 (2014).Crossref, Medline, Google Scholar31 Cockburn AF, Dehlin JM, Ngan T et al. High throughput DNA sequencing to detect differences in the subgingival plaque microbiome in elderly subjects with and without dementia. Investig. Genet. 3(1), 19 (2012).Crossref, Medline, CAS, Google Scholar32 Harach T, Marungruang N, Dutilleul N et al. Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota. arXiv:1509.02273v2 [q-bio.MN] (2015).Google Scholar33 Wu S, Yi J, Zhang YG, Zhou J, Sun J. Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model. Physiol. Rep. 3(4), e12356 (2015).Crossref, Medline, Google Scholar34 van Nood E, Vrieze A, Nieuwdorp M et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N. Engl. J. 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The author is listed as inventor on Finnish patent application 20145492. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript.No writing assistance was utilized in the production of this manuscript.PDF download
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