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Blood Pressure Changes During Short-Term Fluoxetine Treatment

1999; Lippincott Williams & Wilkins; Volume: 19; Issue: 1 Linguagem: Inglês

10.1097/00004714-199902000-00004

1533-712X

Jay D. Amsterdam, Felipe Garcı́a-España, Jan Fawcett, Frederick Quitkin, Frederick W. Reimherr, Jerrold F. Rosenbaum, Charles M. Beasley,

Blood Pressure and Hypertension Studies

Recent reports of sustained hypertension in some patients receiving venlafaxine have rekindled concerns about antidepressant-induced hypertension. This study examined sitting and standing systolic and diastolic blood pressure, pulse rate, and rate of sustained hypertension in 796 depressed patients (mean +/- SD age, 40 +/- 11 years) taking fluoxetine 20 mg daily for up to 12 weeks. A modest reduction in sitting and standing systolic (p < 0.001) and diastolic (p < 0.001) blood pressure measures were observed in the entire patient sample. Patients with pretreatment diastolic blood pressure < 60 mmHg (N = 32) showed a modest increase in mean diastolic blood pressure (p < 0.001), whereas patients with pretreatment diastolic blood pressure >or=to90 mmHg and <or=to 95 mmHg (N = 57) had a modest reduction in mean diastolic blood pressure (p < 0.001). Patients with preexisting, stable cardiovascular disease (including hypertension) (N = 35) showed no significant blood pressure change (p = not significant). Of the patients receiving fluoxetine, 1.7% had sustained hypertension for >or=to3 consecutive clinic visits-a rate significantly lower than that previously reported with venlafaxine (4.8%) ([chi squared] = 13.3, p < 0.001) and similar to that previously seen with placebo (2.1%). In conclusion, these data demonstrate a low rate of sustained hypertension (1.7%) during short-term fluoxetine treatment. (J Clin Psychopharmacol 1999;19:9-14)