Synthesis of the Core of Actinophyllic Acid Using a Transannular Acyl Radical Cyclization
2012; American Chemical Society; Volume: 14; Issue: 6 Linguagem: Inglês
10.1021/ol300280s
ISSN1523-7060
AutoresHisaaki Zaimoku, Tsuyoshi Taniguchi, Hiroyuki Ishibashi,
Tópico(s)Alkaloids: synthesis and pharmacology
ResumoA synthetic study of actinophyllic acid based on an original strategy has been described. A transannular acyl radical cyclization allowed us to obtain a key bicyclo[3.3.2] framework, and construction of a core of the target alkaloid has been accomplished by subsequent introduction of a C2 unit.
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