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Albumin dialysis using the molecular adsorbent recirculating system

2001; Lippincott Williams & Wilkins; Volume: 10; Issue: 6 Linguagem: Inglês

10.1097/00041552-200111000-00008

1473-6543

Steffen Mitzner, Jan Stange, Sebastian Klammt, P Peszynski, Reinhard Schmidt,

Liver Disease Diagnosis and Treatment

Liver support systems based on either dialysis, filtration, and adsorption or plasmaperfusion over hepatocytes have been tested clinically with varying success. A new approach in this field is the selective removal of albumin-bound end products of metabolism. This can be achieved in a high-flux dialysis setting by the addition of human serum albumin as a molecular adsorbent to the dialysate with subsequent recirculation of the dialysate over sorbents (molecular adsorbent recirculating system). The current knowledge about the albumin dialysis molecular adsorbent recirculating system is reviewed in this article.