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Multifunctional Fe 3 O 4 /TaO x Core/Shell Nanoparticles for Simultaneous Magnetic Resonance Imaging and X-ray Computed Tomography

2012; American Chemical Society; Volume: 134; Issue: 25 Linguagem: Inglês

10.1021/ja3016582

1943-2984

Jeong Yong Lee, Hye Rim Cho, Myoung Hwan Oh, Soo Hong Lee, Kang Min Kim, Byung Hyo Kim, Kwangsoo Shin, Tae-Young Ahn, Jin Woo Choi, Young-Woon Kim, Seung Hong Choi, Taeghwan Hyeon,

Lanthanide and Transition Metal Complexes

Multimodal imaging is highly desirable for accurate diagnosis because it can provide complementary information from each imaging modality. In this study, a sol-gel reaction of tantalum(V) ethoxide in a microemulsion containing Fe(3)O(4) nanoparticles (NPs) was used to synthesize multifunctional Fe(3)O(4)/TaO(x) core/shell NPs, which were biocompatible and exhibited a prolonged circulation time. When the NPs were intravenously injected, the tumor-associated vessel was observed using computed tomography (CT), and magnetic resonance imaging (MRI) revealed the high and low vascular regions of the tumor.