Novel Method for Synthesizing Spiro[4.5]cyclohexadienones through a Pd-Catalyzed Intramolecular ipso -Friedel−Crafts Allylic Alkylation of Phenols
2010; American Chemical Society; Volume: 12; Issue: 21 Linguagem: Inglês
10.1021/ol102190s
ISSN1523-7060
AutoresTetsuhiro Nemoto, Yuta Ishige, Mariko Yoshida, Yuta Kohno, Mutsumi Kanematsu, Yasumasa Hamada,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoThe first successful Pd-catalyzed intramolecular ipso-Friedel−Crafts allylic alkylation of phenols, which provided a new access to spiro[4.5]cyclohexadienones, is described. The present method could be applied to catalytic enantioselective construction of an all-carbon quaternary spirocenter.
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