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Chromanones with Leishmanicidal Activity from Calea uniflora

2007; De Gruyter; Volume: 62; Issue: 5-6 Linguagem: Inglês

10.1515/znc-2007-5-606

1865-7125

Andréa Mendes do Nascimento, Fernanda Cristina Costa, Otávio Henrique Thiemann, Dionéia Camilo Rodrigues de Oliveira,

Chemical synthesis and pharmacological studies

The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6- (1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chromanones 1 and 2 showed significant growth inhibition of the parasite in the micrograms per milliliter range.