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Cytotoxic Cucurbitacin Constituents from Sloanea z uliaensis

2003; American Chemical Society; Volume: 66; Issue: 11 Linguagem: Inglês

10.1021/np0303106

1520-6025

Nelson Rodríguez, Yelkaira Vásquez, Ahmed A. Hussein, Phyllis D. Coley, Pablo N. Solís, Mahabir P. Gupta,

Sesquiterpenes and Asteraceae Studies

A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1−3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.