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The Prognostic Value of Serum Gamma Glutamyl Transferase Activity on Admission in Patients With STEMI Undergoing Primary PCI

2011; SAGE Publishing; Volume: 63; Issue: 8 Linguagem: Inglês

10.1177/0003319711431880

1940-1574

Mahmut Akpek, Deniz Elcık, Nihat Kalay, Mikail Yarlıoğlueş, Orhan Doğdu, Ömer Şahin, İdris Ardıç, Abdurrahman Oğuzhan, Ali Ergin, Mehmet Güngör Kaya,

Liver Disease Diagnosis and Treatment

We assessed the association between serum gamma glutamyl transferase (GGT) activity with postprimary percutaneous coronary intervention (PCI) coronary flow and in-hospital major advanced cardiac events (MACEs) in patients with ST elevation myocardial infarction (STEMI). Patients with STEMI (n = 425; males 78%; mean age 60 ± 13 years) were enrolled. Patients were divided into 3 GGT tertiles and 2 groups according to thrombolysis in myocardial infarction (TIMI) flow grade. The TIMI flow percentages were similar in the 3 GGT tertiles (32%, 45%, and 42%, respectively, P = .336). Total MACE increased with GGT tertiles (among tertiles, respectively; P < .001). The total MACE was significantly higher in impaired flow group than in normal flow group (23% vs 7%; P < .001). At multivariate analyses, serum GGT activity was an independent predictor of in-hospital MACE (odds ratio [OR] 1.12, 95% confidence interval [CI] 1.01-1.33; P < .001). In conclusion, serum GGT activity is associated with in-hospital MACE in patients with STEMI undergoing primary PCI.