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Changes in Serum Osteocalcin Levels in the Follow-Up of Kidney Transplantation

1997; SAGE Publishing; Volume: 34; Issue: 6 Linguagem: Inglês

10.1177/000456329703400609

1758-1001

M R Bonnin, M. Teresa González, J M Griñó, Josep M. Cruzado, Jordi Bover, José Manuel Martínez, Miguel Navarro,

Bone health and osteoporosis research

Serum osteocalcin, total alkaline phosphatase, intact parathyroid hormone (PTH), creatinine, calcium, and phosphate were determined in 23 kidney cadaveric allograft recipients, immediately before and 0·5, 1, 3 and 6 months after surgery. Immunosuppressive treatment was based on low doses of corticosteroids and cyclosporin combined with antilymphoblast globulin. The decrease in serum creatinine was accompanied by falling PTH concentrations. Serum osteocalcin levels were higher than normal before kidney transplantation and diminished at 0·5 and 1 month after surgery. Significant increases in serum osteocalcin concentrations were observed 3 and 6 months after kidney transplantation with a significant correlation with alkaline phosphatase levels. The increase in serum osteocalcin levels observed in our transplanted patients is not related with a parallel increase in serum creatinine levels nor with an increment in PTH levels; it seems to reflect an increase in the osteoblastic activity, which is not altered by steroid therapy.