Bioceramics Composed of Octacalcium Phosphate Demonstrate Enhanced Biological Behavior
2014; American Chemical Society; Volume: 6; Issue: 19 Linguagem: Inglês
10.1021/am502583p
ISSN1944-8252
AutoresВ. С. Комлев, С. М. Баринов, I. Y Bozo, R. V Deev, I. I Eremin, A. Yu. Fedotov, A N Gurin, Н. В. Хромова, Pavel Kopnin, Е. А. Кувшинова, Vasily Mamonov, V. Rybko, Н. С. Сергеева, A. Yu. Teterina, V. L Zorin,
Tópico(s)Endodontics and Root Canal Treatments
ResumoBioceramics are used to treat bone defects but in general do not induce formation of new bone, which is essential for regeneration process. Many aspects related to bioceramics synthesis, properties and biological response that are still unknown and, there is a great need for further development. In the most recent research efforts were aimed on creation of materials from biological precursors of apatite formation in humans. One possible precursor is octacalcium phosphate (OCP), which is believed to not only exhibit osteoconductivity but possess osteoinductive quality, the ability to induce bone formation. Here we propose a relatively simple route for OCP ceramics preparation with a specifically designed microstructure. Comprehensive study for OCP ceramics including biodegradation, osteogenic properties in ortopic and heterotopic models and limited clinical trials were performed that demonstrated enhanced biological behavior. Our results provide a possible new concept for the clinical applications of OCP ceramics.
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