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Distribution of P32 Following the Injection of TEPA in Rats.

1953; SAGE Publishing; Volume: 83; Issue: 2 Linguagem: Inglês

10.3181/00379727-83-20370

1535-3702

M. L. Crossley, J. B. Allison, Robert W. Wannemacher, J.F. Migliarese, R. P. Parker, Erwin Kuh, Drew R. Seeger, Ruth Partridge,

Bone health and treatments

The distribution of P32 following the injection of tagged TEPA resulted in a fairly uniform distribution of P32 activity throughout the tissues of the body, but there was a greater concentration in the testes and a smaller concentration in bone as compared with injection of inorganic phosphate. There was a gradual accumulation of P32 in the spleen over a period of 30 hours following injection of TEPA, a result not observed with inorganic phosphate. Approximately 60% of the P32 activity in serum or plasma was associated with the globulin fraction, the remainder being in solution after precipitation of all proteins. About 20% of P32 was associated with nuclei and/or relatively heavy cellular components from liver, testes, and tumor tissue, most of the remaining activity being found in the protein-free filtrate. Some 65% of the activity was excreted over a period of 30 hours.