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Central-Nervous-System Lymphoma Related to Epstein–Barr Virus

1983; Massachusetts Medical Society; Volume: 309; Issue: 13 Linguagem: Inglês

10.1056/nejm198309293091301

1533-4406

Fred H. Hochberg, George Miller, Robert T. Schooley, Martin Hirsch, Paul M. Feorino, Werner Henle,

CNS Lymphoma Diagnosis and Treatment

We have studied five cases suggesting a relation between Epstein-Barr virus infection and primary lymphoma of the central nervous system. A 48-year-old man had primary lymphoma of the central nervous system in the absence of systemic lymphoma or immunosuppression. Development of the tumor was associated with serologic evidence suggesting a recent primary infection with Epstein-Barr virus. DNA preparations from tumor tissue, but not from adjacent normal brain tissue, contained Epstein-Barr virus genomes when hybridized with a probe consisting of the BamHI K fragment of Epstein-Barr virus strain FF41. Evaluation of serum samples from four additional patients with central-nervous-system lymphoma revealed patterns of Epstein-Barr virus-specific antibody that were suggestive of an ongoing infection with EBV. Our results suggest induction of the lymphoma by Epstein-Barr virus.