Cadmium, lead, copper and zinc in food, feces and organs of humans - Interrelationships in food and feces and interactions in the liver and the renal cortex.
1977; Keio University School of Medicine; Volume: 26; Issue: 2 Linguagem: Inglês
10.2302/kjm.26.63
ISSN1880-1293
Autores Tópico(s)Heavy Metal Exposure and Toxicity
ResumoThe concentrations of Cd, Pb, Cu and Zn in food, feces and organs were analyzed in order to study the interrelationships among these metals in humans. Correlation coefficients and the ratio of all 4 metals in these media were calculated, and the following results were obtained: the ratios of Cd to Cu and Cd to Zn in the renal cortex showed 100 times higher and those ratios in the liver showed 10 times higher than those in food and feces. How-ever, Pb/Cu and Pb/Zn ratios did not vary in these media. Intimate correlations between Cd and Zn were found in the organs in spite of the fact that they showed no correlation in food and feces. Cu and Zn indicated high correlations in food, feces and renal cortex, but not in the liver. Thus this study indicates that the proportions of the metals ingested via food and excreted in feces are almost the same, i.e., the absorption rates are not greatly different. However, once absorbed, the relationships among the metals are markedly altered, suggesting different metabolism by individual metal and/ or possibly metal-metal interactions in the human organs, particularly in the renal cortex and the liver.
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