Paracetamol Metabolism in Indian Population
2011; Thieme Medical Publishers (Germany); Volume: 52; Issue: 10 Linguagem: Inglês
10.1055/s-0031-1299964
ISSN1616-7066
AutoresSantosh Pabba, Sambamurthy Bolla, K. Rajnarayana, Madhusudana R. Chaluvadi, D. R. Krishna,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoTo investigate the profile of paracetamol (CAS 103-90-2, Calpol®) metabolism in Indian population and to compare with the profiles of studies conducted in other populations, a study was conducted in 100 healthy male human volunteers. After an overnight fast, the volunteers were administered an oral dose of 1 g of paracetamol, urine was collected up to 8 h and samples were analyzed by high performance liquid chromatography for the estimation of urinary recovery of paracetamol and its metabolites, i.e. sulphate, glucuronide, cysteine and mercapturate conjugates. 25.29 ± 5.5 (mean ± S.D.) % of sulphate conjugate, 60.55 ± 8.5 % of glucuronide conjugate, 5.05 ± 2.1 % of unchanged paracetamol, 2.76 ± 2.4 % of cysteine conjugate and 6.37 ± 3.8 % of mercapturate conjugate were recovered. The mean combined recovery of glutathione conjugates (9.13 %) in Indians is found to be very high and is equal to that in Caucasians of Scotland (9.3 %), which indicates that Indians are equally predisposed to hepatotoxicity as Caucasians.
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