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Engineering analysis of penile hemodynamic and structural-dynamic relationships: Part I—Clinical implications of penile tissue mechanical properties

1998; Springer Nature; Volume: 10; Issue: 1 Linguagem: Inglês

10.1038/sj.ijir.3900310

1476-5489

Daniel Udelson, Ashima Nehra, D. Hatzichristou, Kazem M. Azadzoi, RB Moreland, J Krane, I Sáenz de Tejada, Irwin Goldstein,

Hormonal and reproductive studies

Purpose: The least investigated physical determinant of penile rigidity has been penile tissue material properties. The goals in this study (Part I) were to define two penile mechanical parameters, cavernosal expandability X and tunical distensibility VE/VF, determine their magnitudes in humans and develop an analytical expression for penile volume as a function of these two tissue characteristics and intracavernosal pressure. Methods: Dynamic infusion pharmacocavernosometry was performed in 21 impotent patients (age 43±19 y) to provide human geometric, hemodynamic and structural data. A mathematically derived model of hemodynamic and structural-dynamic characteristics of penile erection was developed (Parts I, II, III) incorporating penile tissue mechanical qualities. Results: Cavernosal expandability X provided a measure of the ability to approach maximum volume at relatively low intracavernosal pressures. Tunical distensibility VE/VF denoted the maximal erect to flaccid penile volume ratio. The magnitudes of X and VE/VF in the study population were 0.04–0.17 mmHg−1 and 1.7–5.0 respectively. Conclusions: Enabling penile volume to be derived as a function of tissue mechanical characteristics and pressure, allows for penile rigidity to be expressed (in Part II) as a function of pressure, geometry and tissue qualities.