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CLINICOPATHOLOGIC FEATURES OF EARLY GASTRIC CARCINOMA WITH LIVER METASTASES

1999; Japan Surgical Association; Volume: 60; Issue: 10 Linguagem: Inglês

10.3919/jjsa.60.2578

1882-5133

Sho Ishihara, Akio Yanagisawa, Hirotoshi Ohta, Masashi Ueno, Masami Arai, Makoto Seki, Norihiro Kokudo, Keiichiro Ohta, Takashi Takahashi, Mitsumasa Nishi,

Gastrointestinal Tumor Research and Treatment

Liver metastasis has the highest incidence of course of death in patients with early gastric carcinoma. We analyzed 14 patients with early gastric carcinoma and liver metastasis clincopathologically to ascertain the clinicopathologic features of the high risk group for liver metastasis in early gastric carcinoma. A series of 304 patients with early gastric carcinoma without liver metastasis were served as controls. The clinicopathologic features of early gastric carcinomas with liver metastasis are as follows; 1) tumor site in the lower part of the stomach; 2) macroscopic tumors of the mixed type (IIa+IIc); 3) submucosal tumors (sm 2sm 3); 4) histological tumor type of tubular or poorly differentiated adenocarcinoma, and cancer stroma of medullary type; 5) marked intestinal metaplasia of mucosa around tumors; 6) marked vessel invasion; and 7) high incidence of lymph node involvement. Patients with these features are defined as belonging to the high risk group for liver metastasis who would require some operation in proportion to advanced gastric carcinoma, strict observation of clinical course, and adjuvant chemotherapy.