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Effect of Cortisone and ACTH During Sensitization on Eosinophils and Anaphylaxis in Guinea Pigs

1951; SAGE Publishing; Volume: 77; Issue: 1 Linguagem: Inglês

10.3181/00379727-77-18704

1535-3702

Peter Dews, Charles F. Code,

Stress Responses and Cortisol

Two series of 36 and 24 guinea pigs were studied. Cortisone was given to a third of the animals, ACTH to a third and the remaining third served as controls. The administration of the hormones, in moderate or large doses, was started before giving the sensitizing injections of egg white, and was continued while they were being given and for varying periods after their completion. N treatment had any effect on the severity of anaphylactic reactions induced by the subsequent intravenous injection of the antigen. Used in adequate amounts, both hormones produced pronounced and sustained reductions in the number of circulating eosinophils in the blood of male and nonpregnant female guinea pigs.