Portal de Periódicos da CAPES

Effects of Prostaglandins PGE2 and PGF2a on the Adenyl Cyclase Activity of Various Segments of the Immature Rabbit Oviduct and Uterus

1973; SAGE Publishing; Volume: 143; Issue: 2 Linguagem: Inglês

10.3181/00379727-143-37360

1535-3702

Leonard J. Lerner, Paolo Carminati, Benjamin Rubin,

Neuropeptides and Animal Physiology

Immature rabbit oviducts and uteri incubated in the presence of PGE2 showed increases in the percent conversion of 3H-nucleotides to 3H-cAMP. The different segments of the oviduct had similar adenyl cyclase activities in the absence of prostaglandin. In the presence of PGE2, however the degrees of response varied. The adenyl cyclase activities of oviductal ampulla, oviductal isthmus, uterotubal junction and uterus were 2, 3, 4, and 2 times those of their controls, respectively. Addition of theophylline to the incubation mixture enhanced the level of cAMP formation and the response to PGE2·PGF2α, at a concentration (10 μg/ml) that produced a maximal response for PGE2, did not significantly alter the adenyl cyclase activity in any area of the oviduct or uterus.