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BIBTEX RIS

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

2016; Research Foundation of Ribeirão Preto; Volume: 15; Issue: 1 Linguagem: Inglês

10.4238/gmr.15017478

ISSN

1676-5680

Autores

Carolina René Hoelzle, K.C.S.F. Magalhães, Stela Seixas Carvalho, Geraldine Alves dos Santos, Igor Mendes Maia, Millena Carolina Pereira Silva Sousa, J.S. Andrade-Filho, Geraldo Magela Gomes da Cruz, Renata Toscano Simões,

Tópico(s)

Blood Coagulation and Thrombosis Mechanisms

Resumo

We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls.A total of 104 patients with CRC and 84 controls were evaluated.Peripheral blood was collected from both groups and DNA extraction was performed for -1562C/T genotyping; the plasma was used for MMP-9 quantification.The CT genotype was associated with increased MMP-9 expression (P = 0.0211).High levels of protein, independently of polymorphisms, were observed in the patient group (P < 0.0001) compared to controls.Mucinous tumors with signet ring cells were more frequent in females (P = 0.0177).Overall, patients older than 50 years showed a significant risk of developing CRC (P = 0.0001).MMP-C.R. Hoelzle et al.©FUNPEC-RP www.funpecrp.com.brGenetics and Molecular Research 15 (1): gmr.15017478 9 plasma expression was increased in patients with CRC compared to controls, particularly in those with the heterozygous -1562CT genotype.

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