Effects of selenium deficiency on vitamin E metabolism in rats.
1977; Center for Academic Publications Japan; Volume: 23; Issue: 4 Linguagem: Inglês
10.3177/jnsv.23.273
ISSN1881-7742
Autores Tópico(s)Antioxidant Activity and Oxidative Stress
ResumoThe metabolism of radioactive vitamin E in selenium defi-cient rats has been compared to the metabolism of this vitamin in rats supplemented with 0.1 ppm selenium as sodium selenite in the diet. After dosing with tritiated α tocopherol, the plasma level of radioactivity remained elevated through 48 hours in deficient rats. In contrast, a decline to nearly background levels occurred within 12 hours in the sup-plemented rats. The uptake and release of radioactivity in the erythro-cytes and liver were found to be more rapid in deficient rats than in sup-plemented ones. A 65% greater increase in excretion of radioactivity oc-curred in the urine from deficient rats as compared to supplemented ones. These data indicate that vitamin E is metabolized more rapidly in selenium deficient rats than in supplemented ones.
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