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An Efficient Generation of a Functionalized Tertiary-Alkyl Radical for Copper-catalyzed Tertiary-Alkylative Mizoroki-Heck type Reaction

2013; American Chemical Society; Volume: 135; Issue: 44 Linguagem: Inglês

10.1021/ja409661n

1943-2984

Takashi Nishikata, Yushi Noda, Ryo Fujimoto, Tomomi Sakashita,

Radical Photochemical Reactions

α-Halocarbonyl compounds undergo β-hydrogen elimination to give conjugated olefins in the presence of a transition-metal catalyst. However, a copper/triamine catalyst system can induce the alkylative Mizoroki–Heck reaction of styrenes with tertiary-alkyl halides possessing a withdrawing group under very mild conditions. This reaction provides an efficient synthetic methodology for tertiary-alkylated styrenes.