Glutamate receptors in astrocytic end-feet
1994; Lippincott Williams & Wilkins; Volume: 5; Issue: 10 Linguagem: Inglês
10.1097/00001756-199406020-00011
ISSN1473-558X
AutoresCarlos Matute, Kike Gutiérrez-Igarza, Carlos Río, Ricardo Miledi,
Tópico(s)Neuroinflammation and Neurodegeneration Mechanisms
ResumoGlial cells in the mammalian central nervous system, like neurons, possess glutamate receptors suggesting that neuronal-glial communication via neurotransmitters is an important component of brain function. In the bovinecorpus callosum,GLUR-1, an a-amino-3-hydroxy-5-methyl-4 isoxazolepropionate (AMPA)/kainate receptor subtype, is a major type of glutamate receptor. It is distributed along astrocytic processes and it is particularly abundant in the end-feet and the glial fibers surrounding the capillaries. This close spatial relationship between GLUR-1 receptors in astrocytes and endothelial cells suggests that these receptors may be activated by glutamate transported across the blood-brain barrier and thus regulate the barrier itself by ensuing astrocyte-endothelial cell interactions.
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