Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12.
1990; National Institutes of Health; Volume: 46; Issue: 2 Linguagem: Inglês
Autores
Graham C. Webb, Rohan T. Baker, K Fagan, Philip G. Board,
Tópico(s)Glycosylation and Glycoproteins Research
ResumoThe chromosomal location of the human ubiquitin genes has been evaluated by in situ hybridization. Because of the conservation of the ubiquitin sequence, coding-region probes cannot distinguish between specific ubiquitin genes and reveal ubiquitin sequences in a number of different chromosomal regions. The major sites of hybridization with a coding-region probe include 17p11.1-p12, 12p24.2-q24.32, and 2q21-q24, with weaker hybridization over 1p3, 1q4, 2q3, and 13q. Hybridization with a probe isolated from the UbB gene intron indicated that this gene is located within the region 17p11.1-17p12. This region showed the strongest hybridization with the coding-region probe and is presumably also the location of the duplicated UbB pseudogene.
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