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Activation of TRAIL ‐ DR 5 pathway promotes sensorineural degeneration in the inner ear

2016; Wiley; Volume: 15; Issue: 2 Linguagem: Inglês

10.1111/acel.12437

1474-9726

Shyan‐Yuan Kao, Vítor Yamashiro Rocha Soares, Arthur G. Kristiansen, Konstantina M. Stanković,

Inflammasome and immune disorders

Summary Tumor necrosis factor ( TNF ) family cytokines are important mediators of inflammation. Elevated levels of serum TNF ‐α are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF ‐related apoptosis‐inducing ligand ( TRAIL ) and its signaling death receptor 5 ( DR 5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR 5‐blocking antibodies.