Portal de Periódicos da CAPES

Novel Chromone Derivatives from the Fungus Aspergillus v ersicolor Isolated from the Marine Sponge Xestospongia e xigua

2002; American Chemical Society; Volume: 66; Issue: 1 Linguagem: Inglês

10.1021/np020196b

1520-6025

Wenhan Lin, Gernot Brauers, Rainer Ebel, Victor Wray, Albrecht Berg, Sudarsono Sudarsono, Peter Proksch,

Chemical synthesis and alkaloids

From the marine sponge Xestospongia exigua collected in Indonesia the fungus Aspergillus versicolor was isolated. Following cultivation in a seawater-based medium seven new angular tricyclic chromone derivatives (1−7) were obtained from the mycelia and culture filtrate. Compounds 2−7 contain an additional dihydropyran ring system which is replaced by a pyridine ring in 1. The structures of the new natural products were established on the basis of extensive one- and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, NOE difference spectra) as well as on mass spectral analysis.