Produção Nacional
Revisado por pares
Synthesis and Anti-Paracoccidioides Activity of Calix[n]arenes
2011; Bentham Science Publishers; Volume: 9; Issue: 1 Linguagem: Inglês
10.2174/157018012798192991
ISSN1875-628X
AutoresMarcilene Coimbra de Oliveira, Fabiano Souza Reis, Ângelo de Fátima, Thaís Furtado Ferreira Magalhães, Danielle L. da Silva, Raphael Rodrigues Porto, Giselle Almeida Watanabe, Cleide Viviane Buzanello Martins, Daniel Leite da Silva, Ana Lúcia Tasca Góis Ruiz, Sérgio Antônio Fernandes, João Ernesto de Carvalho, Maria Aparecida de Resende,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoFungi are some of the most neglected pathogens in terms of new drug discovery. Paracoccidioidomycosis, an endemic disease to South America, is caused by dimorphic fungi of Paracoccidioides genus. Reasonable citotoxicity, limited efficacy, and frequent use of current commercial antifungals have led to the emergence of resistance. Thus, the development of new antifungals with more selectivity and large spectrum of action is mandatory. In this work, six calix[n]arenes were synthesized and their activity explored against seven isolates of P. brasiliensis and P. lutzii. p-tert- Butylcalix[4]arene (CX1) was the most potent compound against fungal cells and exhibited the lowest toxicity on healthy mammalian cells (V79, hamster lung and MDCK, dog kidney). This is the first report on the effect of calix[n]arenes as growth inhibitors of Paracoccidioides fungi. Keywords: Calix[n]arenes, P-tert-Butylcalix[n]arene, Antifungal, Paracoccidioides genus, Paracoccidioidomycosis, Dimorphic fungi, Mammalian cells, phenolic, anti-Paracoccidioides, Dimorphic fungus, pathogens, P. brasiliensis, P. lutzii
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