A Luminescent and Biocompatible PhotoCORM
2012; American Chemical Society; Volume: 134; Issue: 44 Linguagem: Inglês
10.1021/ja3084434
ISSN1943-2984
AutoresAgustin E. Pierri, Alessia Pallaoro, Guang Wu, Peter C. Ford,
Tópico(s)Heme Oxygenase-1 and Carbon Monoxide
ResumoThe water-soluble rhenium(I) complex fac-[Re(bpy)(CO)3(thp)]+ (1) [CF3SO3– salt; bpy = 2,2′-bipyridine, thp = tris(hydroxymethyl)phosphine] is both strongly luminescent and photoactive toward carbon monoxide release. It is stable in aerated aqueous media, is incorporated into cells from the human prostatic carcinoma cell line PPC-1, and shows no apparent cytotoxicity. Furthermore, the solvated Re(I) photoproduct of CO release (2) is also luminescent, a feature that allows one to track the transformation of 1 to 2 inside such cells using confocal fluorescence microscopy. In this context, 1 is a very promising candidate as a photoactivated CO releasing moiety (photoCORM) with potential therapeutic applications.
Referência(s)