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Fast Distinguishment of Unknown from Known Compounds. Dereplication of Natural Products Using LC/MS.

1997; Mass Spectrometry Society of Japan; Volume: 45; Issue: 3 Linguagem: Inglês

10.5702/massspec.45.295

1880-4225

Nobuharu Shigematsu,

Analytical Chemistry and Chromatography

Development of analytical instruments, especially of LC/MS, led us to a quick and effective identification of known natural compounds. Dereplication is an important concept in the development of useful medicines that are derived from natural products. Separation, analysis, and searching are important factors for the dereplication.This paper establishes a method for doing the dereplication and shows the know-how of each step.