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Revisão Revisado por pares
BIBTEX RIS

Homocysteine and Atherothrombosis

1998; Massachusetts Medical Society; Volume: 338; Issue: 15 Linguagem: Inglês

10.1056/nejm199804093381507

ISSN

1533-4406

Autores

George N. Welch, Joseph Loscalzo,

Tópico(s)

Pituitary Gland Disorders and Treatments

Resumo

In 1969, McCully made the clinical observation linking elevated plasma homocyst(e)ine concentrations with vascular disease.1 He reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocyst(e)ine concentrations and homocystinuria. On the basis of this observation, he proposed that elevated plasma homocyst(e)ine (hyperhomocyst(e)inemia) can cause atherosclerotic vascular disease. The term "homocyst(e)ine" is used to define the combined pool of homocysteine, homocystine, mixed disulfides involving homocysteine, and homocysteine thiolactone found in the plasma of patients with hyperhomocyst(e)inemia.Subsequent investigations have confirmed McCully's hypothesis, and it has recently become clear that hyperhomocyst(e)inemia is an independent risk factor . . .

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