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Interferon-β Enhances the Synthesis of a 20,000-Dalton Membrane Protein: A Correlation with the Cessation of Cell Growth

1985; Mary Ann Liebert, Inc.; Volume: 5; Issue: 2 Linguagem: Inglês

10.1089/jir.1985.5.305

2332-4007

Ernest Knight, DIANA FAHEY, Dale C. Blomstrom,

Lipid Membrane Structure and Behavior

Interferons (IFNs)-α and -β but not -γ enhance the synthesis of a protein in the membranes of Daudi cells. This protein has an estimated molecular weight of 20,000 (20 kD). Furthermore, the 20-kD protein is enhanced only in the membranes of cells whose growth can be inhibited by IFN-β (Daudi, WISH, HL-60, diploid fibroblasts) but not in the membranes of cells whose growth is not inhibited by IFN-β (Namalva, Raji). These data suggest a correlation between the IFN-β-enhanced 20-kD membrane protein and the inhibition of cell growth by IFN-β.