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Comparative Antigenicity of Native and "Desialized"Orosomucoid in Rabbits.

1962; SAGE Publishing; Volume: 111; Issue: 2 Linguagem: Inglês

10.3181/00379727-111-27790

1535-3702

E. Athineos, Micah Thornton, Richard J. Winzler,

Cancer Research and Treatments

Neuraminidase treatment of orosomucoid from human plasma results in an increase in the antigenicity of the glycoprotein in rabbits. Native and desialized orosomucoid react in a qualitatively and quantitatively similar manner with antibodies to the normal or desialized antigen. Thus the sialic acid, though a terminal sugar, is not an important determinant antigenic group.